图书简介
Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.
Preface Contributors The Editors 1. Ribosomal Pauses during Translation and Proteostasis Alejandro Ferrando, Alihamze Fathinajafabadi, Arantxa Martinez- Ferriz and Rosa Farras 2. Protein Folding and Misfolding: Deciphering Mechanisms of Age-Related Diseases Judith-Elisabeth Riemer, Diana Panfilova, Heidi Olzscha 3. Transcriptional Regulation of Proteostatic Mechanisms Marianna Kapetanou, Sophia Athanasopoulou, Efstathios S. Gonos 4. MicroRNAs as Central Regulators of Adult Myogenesis and Proteostasis Loss in Skeletal Muscle Aging Ioannis Kanakis, Ioanna Myrtziou, Aphrodite Vasilaki, Katarzyna Goljanek-Whysall 5. MRNA Granules and Proteostasis in Aging and Age-Related Diseases Fivos Borbolis and Popi Syntichaki 6. Phospholipids and the Unfolded Protein Response Ilias Gkikas and Nektarios Tavernarakis 7. Ubiquitin Ligases Involved in Progeroid Syndromes and Age-Associated Pathologies Lisa Fechtner and Thorsten Pfirrmann 8. Role of Sumoylation in Neurodegenerative Diseases and Inflammation Esmeralda Parra-Peralbo, Veronica Muratore, Orhi Barroso-Gomila, Ana Talamillo, James D. Sutherland and Rosa Barrio 9. Nedd8 and Oxidative Stress Elah Pick and Giovanna Serino 10. Structure, Function and Regulators of the 20s Proteasome Tobias Jung and Annika Hoehn 11. Cellular Responses to Proteasome Impairment Maja Studencka-Turski and Elke Kruger 12. Proteasome Fate in Aging and Proteinopathies Mary A. Vasilopoulou, Nikoletta Papaevgeniou and Niki Chondrogianni 13. The Proteasomal System in Cancer Sema Arslan-Eseryel, Ulkugul Guven and Betul Karademir-Yilmaz 14. Proteostasis and Skin Aging Anne-Laure Bulteau and Bertrand Friguet 15. Reactive Oxygen Species and Protein Homeostasis in Skeletal Muscle Regeneration Sofia Lourenco Dos Santos, Aurore L’Honore and Isabelle Petropoulos 16. Protein Degradation in Cardiac Health and Disease Xuejun Wang 17. Autophagy in Aging and Oxidative Stress Dimitra Ranti, Anna Gioran and Niki Chondrogianni 18. Autophagy in Aging and Longevity Exemplified by the Aging Heart Steffen Haseli and Christiane Ott Index
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