图书简介
Peroxidasins are a family of heme peroxidases that play a novel role in tissue biogenesis and matrix assembly. Mammalian heme peroxidase enzymes are critical for immune responses and disease prevention. Although highly beneficial, overproduction drives the development of pathologies, including cardiovascular, neurodegenerative, respiratory, kidney and inflammatory bowel diseases by triggering the initiation of stress-related pathways leading to cell damage and dysfunction. This book highlights the roles of mammalian heme peroxidases, as well as their involvement in immunity and disease, and potential therapeutic approaches to modulate and prevent damaging reactions.
SECTION 1: INTRODUCTION TO MAMMALIAN HEME PEROXIDASES Chapter 1: Evolution, structure and biochemistry of human peroxidases Paul G. Furtmuller, Marcel Zamocky, Stefan Hofbauer, Christian Obinger* Chapter 2: Biosynthesis of mammalian heme proteins, peroxidases and NADPH oxidases William M. Nauseef* Chapter 3: Peroxidasin structure and function Gabor Sirokmany, Hajnal A. Kovacs, Miklos Geiszt* SECTION 2: REACTIVITY OF PEROXIDASE OXIDANTS Chapter 4: Reactivity of peroxidase-derived oxidants with proteins, glycoproteins and proteoglycans Michael J. Davies* Chapter 5: Reactivity of hypochlorous acid (HOCl) with nucleic acids, RNA and DNA. Clare L. Hawkins* Chapter 6: Reactivity of peroxidase oxidants with lipids: The generation of biologically important modified lipids Daniel P. Pike and David A. Ford* Chapter 7: Roles of myeloperoxidase in the oxidation of apolipoproteins: Interest of monitoring MPO oxidation of apolipoproteins A-1 and B-100 to improve the estimation of lipoprotein quality in cardiovascular diseases Catherine Coremans, Karim Zouaoui Boudjeltia, Pierre Van Antwerpen and Cedric Delporte* Chapter 8: Global profiling of cell responses to (pseudo)hypohalous acids Joshua Chandler* SECTION 3: PEROXIDASES IN INNATE IMMUNITY Chapter 9: MPO and immune cell recruitment and activation Anne Klinke and Martin Mollenhauer* Chapter 10: Bactericidal activity of the oxidants derived from mammalian heme peroxidases Heather L. Shearer, Nina Dickerhof and Mark B. Hampton* Chapter 11: Priming the innate immune system to combat respiratory disease Brian Day* SECTION 4: PEROXIDASES IN PATHOLOGY Chapter 12: Imaging the reactivity of MPO in vivo Cuihua Wang, Negin Jalali Motlagh, Enrico G. Kuellenberg, and John W. Chen* Chapter 13: Role of MPO in endothelial dysfunction and cell signaling in atherosclerosis Benjamin Rayner* Chapter 14: MPO in ischemic heart disease Dennis Mehrkens, Simon Geissen, Stephan Baldus, and Volker Rudolph* Chapter 15: Role of MPO in neurodegenerative disease Wanda F. Reynolds* and Richard A. Maki Chapter 16: The pathogenesis and consequences of MPO-dependent ANCA and glomerulonephritis Meghan E. Free*, Dominic J. Ciavatta, J. Charles Jennette and Ronald J. Falk Chapter 17: Role of peroxidasins in disease Gautam Bhave* SECTION 5: PREVENTION OF MPO INDUCED DAMAGE Chapter 18: Structure, function, and mechanistic insights into a novel family of myeloperoxidase inhibitory proteins expressed by Staphylococci Molly Allison, Nitin Mishra and Brian V. Geisbrecht*
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